Table 1. Different Amount of Compounds in the SEDDS Formulations of Carvedilol a.
| Factorial Design Condition | O, g | S, g | CoS, g | O/s ratio | S/CoS Ratio | Polymer | Amount of Polymer | Drug, % | Amount of Drug | |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | + + + | 12 | 4 | 1 | 3.1 | 4.1 | Poloxamer | 0.15 | 1 | 0.17 |
| 2 | + + - | 12 | 4 | 1 | 3.1 | 4.1 | HPMC | 0.15 | 1 | 0.17 |
| 3 | - + + | 12 | 12 | 3 | 1.1 | 4.1 | Poloxamer | 0.15 | 1 | 0.27 |
| 4 | + - + | 12 | 4 | 2 | 3.1 | 2.1 | Poloxamer | 0.15 | 1 | 0.18 |
| 5 | - + - | 12 | 12 | 3 | 1.1 | 4.1 | HPMC | 0.15 | 1 | 0.27 |
| 6 | + - - | 12 | 4 | 2 | 3.1 | 2.1 | HPMC | 0.15 | 1 | 0.18 |
| 7 | - - + | 12 | 12 | 6 | 1.1 | 2.1 | Poloxamer | 0.15 | 1 | 0.3 |
| 8 | - - - | 12 | 12 | 6 | 1.1 | 2.1 | HPMC | 0.15 | 1 | 0.3 |
a Abrevations: CoS, co-surfactant; O, oil; S, surfactant; O/S ratio, oil/surfactant; S/CoS ratio, surfactant/co-surfactant.