Table 6. The Drug Percent Permeated Through Rat Intestine From Different SEDDS Formulations and Control a.
Time, h | Factorial Design Condition | The Drug Percent Permeated Through Rat Intestine | ||||
---|---|---|---|---|---|---|
0.5 | 1 | 2 | 3 | 4 | ||
1 | + + + | 35.55 ± 6.80 | 45.05 ± 6.65 | 53.23 ± 2.70 | 60.75 ± 5.42 | 69.68 ± 3.51 |
2 | + +- | 22.90 ± 6.71 | 44.59 ± 15.59 | 55.16 ± 7.39 | 60.20 ± 7.46 | 66.44 ± 7.10 |
3 | - + + | 32.59 ± 4.23 | 41.13 ± 4.40 | 53.70 ± 5.33 | 59.46 ± 5.61 | 69.78 ± 5.52 |
4 | + - + | 22.42 ± 6.78 | 26.98 ± 6.63 | 40.05 ± 7.26 | 44.50 ± 7.64 | 49.31 ± 8.57 |
5 | - + - | 18.60 ± 5.06 | 23.69 ± 3.90 | 50.52 ± 2.99 | 54.81 ± 5.22 | 61.29 ± 4.95 |
6 | + - - | 17.25 ± 2.99 | 28.18 ± 2.59 | 37.50 ± 4.82 | 51.49 ± 4.83 | 56.40 ± 5.51 |
7 | - - + | 22.31 ± 4.50 | 26.27 ± 4.80 | 44.63 ± 2.70 | 48.63 ± 2.80 | 54.68 ± 4.34 |
8 | - - - | 26.01 ± 1.02 | 32.10 ± 1.34 | 49.18 ± 2.75 | 54.20 ± 2.29 | 59.70 ± 2.04 |
Control | - | 7.36 ± 0.72 | 12.06 ± 0.53 | 16.23 ± 0.70 | 20.14 ± 0.56 | 25.33 ± 0.48 |
aData are presented as Mean ± SD, n = 5