FIG. 2.

Effect of MPA in L929 cells; effect of MPA on production of infectious reovirus progeny. L929 cells were pretreated with the indicated concentrations of MPA for 1 h before infection with T1L and T3D at an MOI of 0.12 PFU/cell. After virus adsorption, cells were overlaid with fresh MEM that contained the indicated concentrations of MPA and incubated at 37°C. Virus was harvested between 65 and 72 hpi, and viral titer was determined. Results are displayed as the relative titer, with infectious progeny virus produced at each MPA concentration expressed as a proportion of virus produced in the untreated control (0 MPA). The data represent the average of a minimum of three experiments, and the error bars represent 1 standard deviation.