Table 2A.
Alleles frequency of 7 AGT variants and p-values corresponding to the test of allele frequencies differences among treatments for case-only participants among Caucasians (n = 2246).
| AGT variants | Chlorthalidone | Amlodipine | Lisinopril | P-value | |
|---|---|---|---|---|---|
| rs7079 | CC | 437 (45.5%) | 297 (47.7%) | 252 (44.8%) | 0.33 |
| AC | 402 (41.9%) | 258 (41.4%) | 255 (45.4%) | ||
| AA | 121 (12.6%) | 68 (10.9%) | 55 (9.8%) | ||
| rs5051 | TT | 193 (19.8%) | 120 (19.1%) | 108 (18.7%) | 0.22 |
| TC | 435 (44.5%) | 316 (50.2%) | 270 (46.6%) | ||
| CC | 349 (35.7%) | 194 (30.8%) | 201 (34.7%) | ||
| rs3789678 | CC | 779 (79.3%) | 494 (77.8%) | 462 (79.5%) | 0.89 |
| TC | 188 (19.1%) | 132 (20.8%) | 109 (18.8%) | ||
| TT | 16 (1.6%) | 9 (1.4%) | 10 (1.7%) | ||
| rs2493133 | CC | 194 (20.2%) | 117 (18.7%) | 106 (18.5%) | 0.24 |
| TC | 423 (43.9%) | 311 (49.7%) | 268 (46.8%) | ||
| TT | 346 (35.9%) | 198 (31.6%) | 199 (34.7%) | ||
| rs2493129 | GG | 941 (95.1%) | 587 (91.7%) | 551 (93.1%) | 0.01 |
| AG | 46 (4.7%) | 53 (8.3%) | 40 (6.8%) | ||
| AA | 3 (0.3%) | 0 (0%) | 1 (0.2%) | ||
| rs2478544 | GG | 642 (68.4%) | 396 (65.7%) | 386 (68.7%) | 0.36 |
| GC | 263 (28%) | 191 (31.7%) | 154 (27.4%) | ||
| CC | 34 (3.6%) | 16 (2.7%) | 22 (3.9%) | ||
| rs11122576 | AA | 863 (87.6%) | 543 (84.5%) | 493 (83.3%) | 0.07 |
| AG | 112 (11.4%) | 96 (14.9%) | 91 (15.4%) | ||
| GG | 10 (1%) | 4 (0.6%) | 8 (1.4%) | ||
Test of differences between genotype groups: chi-square and Fisher's exact tests. Fisher's exact test was used for SNP which has any cell size less than 10 observations in frequency table.