Figure 2.

(A) Scaled functional sensitivity w as a function of scaled total CD8 density x_T for various scaled TCR/pMHCI off-rates α. (B) Degeneracy curves ℙ(w > ω) for various scaled total CD8 density x_T. (C) The probability ℙ(w > ω) as a function of CD8 density x_T, at a set value of functional sensitivity ω = 0.14. The operating range of the probability ℙ is shown as a function of x_T with dashed lines at ℙ(w > 0.14) = 10⁻⁸ and ℙ(w > 0.14) = 10⁻⁵. Parameters are as follows: $\mathrm{\delta }=300,n=100,{\mathrm{\gamma }}_{\mathrm{kin}}=0.1,{\mathrm{\gamma }}_{\mathrm{off}}=0.5,{\mathrm{\gamma }}_{\mathrm{R}}=1,\mathrm{\kappa }=5.5,m_T=10,r_T=10$. The log-normal distribution has mean 2 and SD 0.2. Changed: ω = 0.14, γ_kin, γ_R,κ and α’s in (A).