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Scaled functional sensitivity w as a function of scaled total CD8 density xT. (A) Curves for various values of the scaled TCR/pMHCI off-rate α. (B) Curves for various values of the dimensionless factor γoff expressing the modulatory effect of CD8 on the TCR/pMHCI off-rate. Parameters, unless stated otherwise, are as follows: δ = 500, n = 100, γkin = 0. 2, γoff = 0. 2, γR = 0. 01, κ = 1, mT = 10, rT = 10, α = 1. Changed: δ, γkin, γR,α,κ, and α’s in (A) and γoff’s in (B).
