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. Author manuscript; available in PMC: 2014 Sep 16.
Published in final edited form as: Mol Psychiatry. 2013 Oct 29;19(1):41–49. doi: 10.1038/mp.2013.145

Figure 1.

Figure 1

Chromosome 4 regional Manhattan plots. (a) European-Americans: regional Manhattan plot for the ADH gene cluster and adjacent regions on chromosome 4 showing the adjusted symptom count meta-analysis P-values from the discovery sample EAs, as well as points for the meta-analysis results after including our replication sample (diamonds). The points are colored based on degree of LD with rs1229984. Square points indicate genotyped SNPs and round points indicate imputed SNPs. All SNPs in the replication sample were genotyped. Data include the GCD sample plus SAGE, and GCD and German replication samples (diamonds). (b) African-Americans: regional Manhattan plot for the ADH gene cluster and adjacent regions on chromosome 4 showing the adjusted symptom count meta-analysis P-values from AAs in the discovery sample, as well as points for the meta-analysis result after inclusion of our replication sample (diamonds). The points are colored based on degree of LD with rs2066702. Square points indicate genotyped SNPs and round points indicate imputed SNPs. All SNPs in the replication sample were genotyped. Data include the GCD sample plus SAGE and the GCD replication sample (diamonds). AA, African-American; EA, European-American; LD, linkage disequilibrium; SAGE, study of addiction: genetics and environment.