. Author manuscript; available in PMC: 2014 Sep 16.

Published in final edited form as: Mol Psychiatry. 2013 Oct 29;19(1):41–49. doi: 10.1038/mp.2013.145

Table 2.

Summary of significant results for the adjusted ordinal model–GWAS sample

									African-Americans					European-Americans					All

Chr	BP	SNP	Effect allele	Ref allele	EAF AA	EAF EA	SNP Type	Gene	GCD P	GCD Beta	SAGE P	SAGE Beta	Meta P	GCD P	GCD Beta	SAGE P	SAGE Beta	Meta P	Meta P
2	136806959	rs925966	C	G	0.35	0.62	NA	NA	5.55E-01	− 0.003	8.58E-01	0.002	6.86E-01	7.87E-05	0.02	4.68E-05	0.03	*1.43E-08*	1.27E-04
4	95583827	rs10031423	C	T	0.46	0.42	INT	PDLIM5	3.79E-01	− 0.005	4.98E-01	− 0.01	2.69E-01	2.04E-02	− 0.01	3.69E-08	− 0.04	*2.01E-08*	1.37E-06
4	99930740	rs58521602	G	A	0.2	0.01	INT	METAP1	3.27E-06	− 0.02	2.94E-03	− 0.02	*3.35E-08*	^a	^a	^a	^a	^a	*3.35E-08*
4	99985350	rs139164451	CT	C	0.19	0.01	NA	NA	1.07E-06	− 0.02	1.29E-03	− 0.02	*5.13E-09*	^a	^a	^a	^a	^a	*5.13E-09*
4	100025015	rs28470942	T	C	0.17	0.01	INT	LOC100507053	*3.41E-08*	− 0.02	1.26E-04	− 0.03	*1.91E-11*	^a	^a	^a	^a	^a	*1.91E-11*
4	100043933	rs28542574	A	G	0.16	0.01	INT	LOC100507053	1.43E-07	− 0.02	4.77E-05	− 0.03	*3.62E-11*	^a	^a	^a	^a	^a	*3.62E-11*
4	100068114	rs116203444	C	T	0.01	0.04	INT	LOC100507053	^a	^a	^a	^a	^a	8.99E-08	− 0.01	1.51E-03	− 0.006	*2.46E-09*	*2.46E-09*
4	100190805	rs28864441	T	C	0.19	0.01	INT	LOC100507053	*6.64E-09*	− 0.02	3.22E-05	− 0.03	*1.06E-12*	^a	^a	^a	^a	^a	*1.06E-12*
4	100225992	rs1693458	T	C	0.23	0.18	NA	NA	4.79E-07	− 0.02	5.72E-04	− 0.03	*1.09E-09*	7.96E-01	− 0.001	4.90E-01	0.004	7.42E-01	7.52E-05
4	100227212	rs3133155	G	C	0.23	0.18	R3	ADH1B	4.29E-07	− 0.02	6.74E-04	− 0.03	*1.13E-09*	8.00E-01	− 0.001	4.90E-01	0.004	7.39E-01	7.73E-05
4	100229017	rs2066702	A	G	0.19	0.01	NSM	ADH1B	*2.18E-09*	− 0.02	2.04E-05	− 0.03	*2.24E-13*	^a	^a	^a	^a	^a	*2.24E-13*
4	100235053	rs1789882	A	G	0.23	0.18	SYN	ADH1B	6.01E-07	− 0.02	5.78E-04	− 0.03	*1.39E-09*	8.15E-01	− 0.001	4.94E-01	0.004	7.33E-01	8.71E-05
4	100236762	rs1693457	C	T	0.23	0.18	INT	ADH1B	5.91E-07	− 0.02	6.49E-04	− 0.03	*1.51E-09*	7.65E-01	− 0.001	5.29E-01	0.003	7.97E-01	7.03E-05
4	100239319	rs1229984	T	C	0.02	0.06	NSM	ADH1B	^a	^a	^a	^a	^a	6.75E-14	− 0.02	8.07E-07	− 0.02	*2.91E-18*	2.91E-18
4	100249210	rs2213042	C	T	0.52	0.29	NA	NA	1.48E-07	− 0.03	2.26E-02	− 0.02	*1.49E-08*	9.81E-01	0.000	8.79E-01	− 0.001	8.98E-01	6.54E-05
4	100250970	rs2173201	A	C	0.44	0.22	NA	NA	4.54E-07	− 0.03	1.42E-03	− 0.03	*2.39E-09*	^a	^a	6.04E-01	− 0.003	^a	4.56E-07
4	100256164	rs58223772	T	TC	0.45	0.22	NA	NA	2.02E-07	− 0.03	4.61E-03	− 0.03	*3.46E-09*	^a	^a	4.45E-01	− 0.004	^a	2.67E-07
4	100258155	rs1614972	T	C	0.52	0.3	INT	ADH1C	1.82E-07	− 0.03	3.17E-02	− 0.02	*2.70E-08*	9.49E-01	0.000	8.29E-01	− 0.001	8.40E-01	7.03E-05
4	100259126	rs3846449	C	T	0.45	0.22	INT	ADH1C	5.87E-07	− 0.03	5.44E-03	− 0.03	*1.14E-08*	^a	^a	5.57E-01	− 0.003	^a	1.06E-06
4	100262547	rs2009181	G	A	0.45	0.22	INT	ADH1C	6.68E-07	− 0.03	4.15E-03	− 0.03	*9.83E-09*	^a	^a	5.49E-01	− 0.003	^a	9.27E-07
4	100266133	rs2241894	C	T	0.45	0.22	SYN	ADH1C	6.65E-07	− 0.03	4.15E-03	− 0.03	*9.79E-09*	^a	^a	5.48E-01	− 0.004	^a	9.20E-07
4	100267372	rs12639833	T	C	0.45	0.22	INT	ADH1C	5.97E-07	− 0.03	4.04E-03	− 0.03	*8.59E-09*	^a	^a	5.52E-01	− 0.003	^a	8.57E-07
4	100268131	rs3762896	T	C	0.46	0.25	INT	ADH1C	7.83E-07	− 0.03	1.33E-03	− 0.03	*3.86E-09*	6.77E-01	0.002	6.91E-01	− 0.002	9.94E-01	4.87E-05
4	100268553	rs4147542	C	T	0.46	0.25	INT	ADH1C	1.51E-06	− 0.03	1.66E-03	− 0.03	*9.14E-09*	6.61E-01	0.002	6.91E-01	− 0.002	9.94E-01	7.75E-05
4	100272147	rs6846835	C	T	0.46	0.25	INT	ADH1C	1.36E-06	− 0.03	1.94E-03	− 0.03	*9.51E-09*	6.70E-01	0.002	8.80E-01	− 0.001	8.57E-01	1.32E-04
4	100273173	rs11936869	C	G	0.46	0.25	INT	ADH1C	1.46E-06	− 0.03	1.96E-03	− 0.03	*1.03E-08*	6.61E-01	0.002	6.91E-01	− 0.002	9.94E-01	8.22E-05
4	100274157	rs4147541	G	C	0.46	0.25	R5	ADH1C	1.45E-06	− 0.03	2.04E-03	− 0.03	*1.06E-08*	6.61E-01	0.002	6.86E-01	− 0.002	9.98E-01	8.22E-05
4	100274983	rs11499824	T	C	0.46	0.25	R5	ADH1C	1.01E-06	− 0.03	1.99E-03	− 0.03	*7.25E-09*	6.59E-01	0.002	7.20E-01	− 0.002	9.70E-01	7.60E-05
4	100277432	rs10006545	A	G	0.46	0.25	NA	NA	7.35E-07	− 0.03	1.56E-03	− 0.03	*4.21E-09*	6.92E-01	0.002	7.00E-01	− 0.002	9.90E-01	5.00E-05
4	100281893	rs10031168	C	T	0.46	0.25	NA	NA	7.21E-07	− 0.03	1.74E-03	− 0.03	*4.57E-09*	6.92E-01	0.002	7.05E-01	− 0.002	9.94E-01	5.28E-05
5	4082501	rs1493464	A	G	0.42	0.56	NA	NA	1.19E-04	0.02	2.68E-06	0.04	*8.59E-09*	5.27E-01	0.004	2.87E-01	− 0.008	7.27E-01	2.06E-04
9	33661286	rs1856202	A	G	0.47	0.17	NA	NA	3.48E-10	0.03	2.07E-02	0.02	*5.99E-11*	5.13E-01	0.003	4.85E-01	0.008	3.39E-01	1.99E-07
19	4680424	rs113683471/rs59514816	G	GAAAAAC	0.29	0.69	INT	LOC100131094	9.53E-01	0.0003	3.06E-01	− 0.01	6.21E-01	1.27E-03	0.02	4.67E-06	0.03	*2.89E-08*	2.32E-04

Abbreviations: BP, base pairs; beta, beta coefficient for the DSM-IV alcohol dependence symptom count; EAF, effect allele frequency; SNP type: INT, intronic; NA, other; NSM, non-synonymous; SYN, synonymous. Results for a SNP are presented if they reached P = 5 × 10⁻⁸ in the overall meta-analysis, the EA meta-analysis or the AA meta-analysis. A more detailed version of this table is included as Supplementary Table S1. Multiple alleles in a column indicate insertion/deletion polymorphisms.

Not tested because of low minor allele frequency, poor imputation quality or model convergence error. Bold and italic indicates genomewide significant results.