Table 1. Systolic BP and cardiac function of the RTEF-/- compared with the control littermates.
WT | RTEF-/- | p value | WT p value | RTEF-/- p value | ||
---|---|---|---|---|---|---|
NCD vs HFD | NCD vs HFD | |||||
Body weight (g) | NCD | 28.4 ± 3.1 | 30 ± 1.1 | 0.23 | ||
HFD | 37.2 ± 3.8 | 38.45 ± 2.6 | 0.43 | 0.0008 | 0.006 | |
Body composition | ||||||
Lean mass | NCD | 68.2 ± 5.2 | 69.72 ± 6 | 0.62 | ||
HFD | 55.7 ± 5.4 | 49.81 ± 5.8 | 0.65 | 0.001 | 0.002 | |
Fat mass | NCD | 12.2 ± 5.7 | 11.72 ± 7.1 | 0.41 | ||
HFD | 29.9 ± 8.9 | 36.87 ± 6.6 | 0.52 | 0.0007 | 0.0002 | |
Heart Rate (bpm) | NCD | 674.9 ± 55.7 | 704.8 ± 38.2 | 0.08 | ||
HFD | 711.9 ± 32.6 | 736.7 ± 25.8* | 0.03 | 0.12 | 0.0007 | |
Systolic BP (mmHg) | NCD | 99.7 ± 3 | 109.1 ± 7 | 0.07 | ||
HFD | 106.5 ± 5 | 111 ± 6 | 0.32 | 0.04 | 0.88 | |
% FS | NCD | 51.0 ± 3.6 | 50 ± 1.4 | 0.57 | ||
HFD | 45.8 ± 2.9 | 37.5 ± 6.2** | 0.01 | 0.02 | 0.001 | |
LVDd | NCD | 2.61 ± 0.1 | 3.21 ± 0.2** | 0.01 | ||
HFD | 3.5 ± 0.3 | 3.53 ± 0.2 | 0.11 | 0.89 | 0.07 | |
LVDs | NCD | 1.27 ± 0.04 | 1.58 ± 0.06* | 0.04 | ||
HFD | 2.2 ± 0.03 | 1.64 ± 0.1** | 0.0008 | 0.06 | 0.08 | |
IVSd + LVPWd | NCD | 1.48 ± 0.06 | 1.44 ± 0.1 | 0.56 | ||
Total Wall Thickness | HFD | 1.3 ± 0.1 | 1.15 ± 0.2 | 0.74 | 0.04 | 0.04 |
IVSs | NCD | 1.6 ± 0.03 | 1.37 ± 0.08* | 0.03 | ||
HFD | 1.3 ± 0.04 | 1.1 ± 0.1** | 0.01 | 0.00002 | 0.02 | |
LVPWS | NCD | 1.3 ± 0.1 | 1.2 ± 0.1 | 0.6 | ||
HFD | 1.0 ± 0.05 | 0.83 ± 0.09** | 0.01 | 0.23 | 0.54 |