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. 2014 Jul 25;15(7):404. doi: 10.1186/s13059-014-0404-4

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© Kakihara et al.; licensee BioMed Central 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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A model of the regulation of box C/D snoRNP biogenesis by the R2TP complex. The R2TP complex regulates the stability of unassembled Nop58 and modulates box C/D snoRNP biogenesis by changes in the subcellular distribution of its protein components in response to growth phase and nutrient conditions. The subcellular translocation of R2TP complex is Kap121- and Crm1-dependent.