Table 1.
Select endothelial genes identified by transcriptional profiling to be differentially regulated by Ad-hKLF4-V5 vs. Ad-NC-V5 Control infected cells
| RefSeq | Gene Name | Ratio | Function |
|---|---|---|---|
| Upregulated | |||
| NM_000050 | Argininosuccinate Synthetase 1 | 25.1 | Vessel Tone |
| NM_000641 | Interleukin 11 | 18.6 | Vasoprotection |
| NM_002514 | Nephroblastoma overexpressed gene | 13.9 | Cell Communication |
| NM_000501 | Elastin | 7.0 | ECM Structural Protein |
| NM_000903 | NAD(P)H dehydrogenase, quinone 1 | 5.8 | Oxidative Stress |
| NM_001025366 | Vascular endothelial growth factora | 4.1 | Angiogenesis |
| NM_000361 | Thrombomodulin | 3.8 | Thrombosis/Hemostasis |
| NM_002133 | Heme oxygenase 1 | 3.2 | Inflammation/Oxidative Stress |
| NM_000603 | Nitric oxide synthase 3 | 2.6 | Vessel Tone |
| NM_000459 | TEK tyrosine kinase | 1.6 | Vascular Development |
| Downregulated | |||
| NM_203500 | Kelch-like ECH-associated protein 1a | -1.4 | Oxidative Stress |
| NM_002015 | Forkhead box O1a | -1.7 | Cell Proliferation/Oxidative Stress |
| NM_001200 | Bone morphogenetic protein 2 | -1.8 | Inflammation |
| NM_016270 | Kruppel-like factor 2 | -2.7 | Vasoprotection |
| NM_001147 | Angiopoietin 2 | -2.9 | Angiogenesis |
| NM_000584 | Interleukin 8 | -2.9 | Inflammation |
| NM_001955 | Endothelin 1 | -3.0 | Vessel Tone |
| NM_000600 | Interleukin 6 | -3.1 | Inflammation |
| NM_003246 | Thrombospondin 1 | -3.5 | Angiogenesis/Platelet Aggregation |
| NM_002982 | Chemokine (C-C motif) ligand 2 | -7.3 | Inflammation |
a
Gene not a published transcriptional target of endothelial KLF2