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. Author manuscript; available in PMC: 2014 Sep 16.
Published in final edited form as: Sci Signal. 2014 Apr 15;7(321):ra36. doi: 10.1126/scisignal.2004762

Fig. 1. miR-3151 reduces the abundance of the TP53 transcript and protein.

Fig. 1

(A) Effect of lentivirally mediated stable expression of miR-3151 or a scramble control on TP53 mRNA abundance in KG1 and MV4-11 cells. Data were normalized to the scramble control value for each cell line (mean ± SD, n = 3 biological replicates; P values based on two-tailed Student’s t test). (B) Effect of lentivirally mediated stable expression of miR-3151, BAALC, or both (miR-3151/BAALC) on TP53 mRNA abundance in KG1 and MV4-11 cells. Data were normalized to the scramble control value for each cell line (mean ± SD, n = 3 biological replicates; P values based on two-tailed Student’s t test). (C) Western blot analysis of TP53 abundance comparing miR-3151–infected MV4-11 cells with scramble control. Left: representative blot; right: quantification of the changes relative to actin as determined by densitometry (mean ± SD, n = 3 blots; P values based on one-tailed Student’s t test).