. 2014 Sep 13;14:77. doi: 10.1186/1471-2253-14-77

Table 1.

Summary data of the pooled studies

Reference	*ref 8*	*ref 9*	*ref 11*	*ref 10*	*ref 12*	*ref 13*	*ref 11*	*ref 11*	*Ref 11*
Characteristics	12 healthy males	12 healthy males	8 healthy females	Orthopaedic surgery	High dependency and IC, 38 cases	Abdominal surgery	Caesarean delivery	Postpartum early	Postpartum late,
Characteristics	12 healthy males	14 healthy females		40 cases	High dependency and IC, 38 cases	20 cases	41 cases	8 cases (15 weeks)	7 cases (1 year)
Study design	Single iv bolus, 0.5 g	iv loading dose 2 g,	single iv bolus, 2 g	Single iv bolus, 1 g	Single iv bolus, 1 g	repeated 1 g, 6 qh	iv loading dose 2 g, maintenance 1 g q6h	iv loading 2 g	iv loading 2 g
Study design	Single iv bolus, 0.5 g	Maintenance 1 g q6h	single iv bolus, 2 g	Single iv bolus, 1 g	Single iv bolus, 1 g	48–72 h	iv loading dose 2 g, maintenance 1 g q6h	iv loading 2 g	iv loading 2 g
Weight	63-83 kg	49-94 kg	54-74 kg	58-107 kg	53-120 kg	57-101 kg	57-110 kg	52-88 kg	50-87 kg
Age	21-25 years	19-34 years	27-37 years	20-88 years	34-82 years	44-85 years	31, SD 5.8 years	31, SD 5.8 years	32, SD 6 years
Sampling strategy	13 samples/case	32 samples/case	4 samples/case	20 samples/case	8 samples/case	2x9 samples/case	4 samples after loading dose + up to 24 h	4 samples/case	4 samples/case,
Sampling strategy	up to 24 h	up to 48 h	up to 6 h	up to 24 h	up to 6 h	up to 72 h	4 samples after loading dose + up to 24 h	up to 6 h	up to 6 h
Analytical technique	HPLC-uv	HPLC-uv	HPLC-uv	HPLC	Fluorescent polarization immuno-assay	HPLC	HPLC-uv	HPLC-uv	HPLC-uv
LLOQ	< 0.1 μg/ml	< 0.02 μg/ml	< 0.08 μg/ml	< 0.25 μg/ml	< 0.2 μg/ml	n.a.	< 0.08 μg/ml	< 0.08 μg/ml	< 0.08 μg/ml
CV%	<6.4%	< 3%	< 15%	< 12.8%	< 7.5%	n.a.	< 15%	< 15%	< 15%

[IC = intensive care; iv = intravenous; SD = standard deviation, HPLC = High Pressure Liquid Chromatography; LLQ = lower limit of quantification; CV = coefficients of variation].