Table 5.
Effect of covariate analysis on variance ( ω 2 ) of Clearance
| Sequential nested model | PPVt 2 | BSVR 2 | BOV 2 | PPVP 2 | PPVP 2 /PPVt 2 |
|---|---|---|---|---|---|
|
No covariates |
0.19 |
0.19 |
0 |
0 |
0 |
|
Allometric scaling (TBW) |
0.19* |
0.10 |
0.0413 |
0.0487 |
0.256 |
|
Allometric scaling (NFM) |
0.19* |
0.0889 |
0.0557 |
0.0454 |
0.239 |
|
F
AGECL
|
0.19* |
0.0799 |
0.0557 |
0.0544 |
0.286 |
|
F
PREGCL
|
0.19* |
0.0803 |
0.0513 |
0.0584 |
0.3074 |
| F ABDCL | 0.19* | 0.0605 | 0.0533 | 0.0762 | 0.401 |
* = assumed from no covariate model estimate.
[PPV = population parameter variability; BSV = between subject variability; BOV = between occasion variability; TBW = total body weight; NFM = normal fat mass; preg = pregnant, abd = abdominal surgery; IC = intensive care patients; ortho = orthopaedic surgery].