Chemical
shift perturbation between TGF-β3 and TGF-β313
and TGF-β3 and TGF-β3H4. (A, C) Chemical shift perturbation
between TGF-β3 and TGF-β313 and TGF-β3 and TGF-β3H4,
respectively. Plotted values correspond to the average chemical shift
perturbation of 1H and 15N chemical shifts given
by Δav = [(Δδ2NH + Δδ2N/25)/2]1/2 between
corresponding residues. (B, D) Residues with the largest shift perturbations
between TGF-β3 and TGF-β313 and TGF-β3 and TGF-β3H4,
respectively, mapped onto the crystal structure of TGF-β3 (PDB
code 1TGJ).