Non-clear cell kidney cancer is a metabolic disease. The genes that are associated with non-clear cell kidney cancer, MET, FLCN, fumarate hydratase, succinate dehydrogenase, TFE3, TFEB, MITF, TSC1, TSC2, and PTEN are all associated with abnormalities of the cell’s ability to sense oxygen, iron, nutrients or energy. Adapted from Linehan, 2012 (88)