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. Author manuscript; available in PMC: 2014 Sep 16.
Published in final edited form as: Semin Oncol. 2013 Aug;40(4):511–520. doi: 10.1053/j.seminoncol.2013.05.009

Figure 2. Non-Clear Cell Kidney Cancer Pathways.

Figure 2

Non-clear cell kidney cancer is a metabolic disease. The genes that are associated with non-clear cell kidney cancer, MET, FLCN, fumarate hydratase, succinate dehydrogenase, TFE3, TFEB, MITF, TSC1, TSC2, and PTEN are all associated with abnormalities of the cell’s ability to sense oxygen, iron, nutrients or energy. Adapted from Linehan, 2012 (88)