Table 2. Baseline Patient Characteristicsa.
At baseline, the mean age of subjects was 60 years old and the mean medication use was just over 2 years in both groups. The mean total UPDRS score in subjects randomized to DBS+ODT was 3 points higher than subjects randomized to ODT; mean UPDRS-III scores were nearly equal.
Characteristic | ODT (n=15) | ODT+DBS (n=15) |
---|---|---|
Gender | ||
Male | 13 | 14 |
Female | 2 | 1 |
Age (yrs) at Enrollment | ||
Mean | 60 ± 7.0 | 60 ± 6.8 |
Range | 51 - 69 | 52 - 74 |
Baseline Medicine Use | ||
Mean Duration (yrs) | 2.1 ± 1.1 | 2.2 ± 1.4 |
Mean L-dopa equivalents (mg/day)b | 569 ± 389 | 451 ± 304 |
Baseline UPDRS Score | ||
Mean Total | 36 ± 15 | 39 ± 14 |
Mean UPDRS-III | 15 ± 7.6 | 15 ± 8.5 |
Reprinted from PD Charles, RM Dolhun, CE Gill, TL Davis, MJ Bliton, MG Tramontana, RM Salomon, L Wang, P Hedera, FT Phibbs, JS Neimat, PE Konrad, Deep brain stimulation in early Parkinson's disease: Enrollment experience from a pilot trial, 18 / 3, 268-73, 2011, with permission from Elsevier.
100 mg of Levodopa with a dopa-decarboxlase inhibitor = 130 mg of controlled-release Levodopa reparations = 83 mg of Levodopa with dopa-decarboxylase and COMT inhibitors = 1 mg of pergolide, pramipexole or lisuride = 3 mg of ropinirole [20].