FIG. 4.

(A) Perturbation of the dimerization of KSHV Pr by the KSDD peptide. The thick black line represents 5 μM KSHV Pr, showing the equilibrium between monomer and dimer. The amounts of the two fractions are almost equal at this concentration. The thin black line represents 5 μM KSHV Pr in the presence of 500 μM KSDD peptide, showing that dimerization is disrupted by the KSDD peptide. (B) SDS-PAGE of each fraction in the gel filtration chromatography experiments. KSHV Pr was observed in the dimer fraction (d) in the absence of the KSDD peptide but was almost completely absent in the presence of the KSDD peptide.