Table 1. The sirtuin sir-2 gene family in C. elegans.
| SIR-2 | Mutant strain | Phenotype | Localization | Interaction partners | BlastP similarity |
|---|---|---|---|---|---|
| SIR-2.1 | sir-2.1 (ok434)III | Superficially wild-type13 | nucleus12,13 | PAR-5 (14–3-3), CEP-1 (p53), DAF-16 (FoxO), H3K9 (H3K9)12 | 44% SIRT1 |
| SIR-2.2 |
sir-2.2 (tm2648)X sir-2.2 (tm2673)X |
Superficially wild-type26 | mitochondria26 | PYC-1 (PC), PCC-1 (PCC), F32B6.2 (MCCC)26 | 49% SIRT4 |
| SIR-2.3 |
sir-2.3 (ok444)X |
Superficially wild-type26 | mitochondria26 | PYC-1 (PC), PCC-1 (PCC), F32B6.2 (MCCC)26 | 42% SIRT4 |
| SIR-2.4 | sir-2.4 (tm2817)I | Sensitive to stress27,28 | nucleus, nuclear membrane, P-granules27 | K08F4.2 (G3BP),27 DAF-16 (nd)28 | 38% SIRT6 |
The SIR-2-interactions are evolutionarily conserved (mammalian homologs in brackets). SIR-2.2 and SIR-2.3 interact with mitochondrial biotin-dependent carboxylases: PC, pyruvate carboxylase; PCC, propionyl-CoA carboxylase; MCCC, methylcrotonyl-CoA carboxylase; nd, not determined.