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. Author manuscript; available in PMC: 2014 Sep 16.
Published in final edited form as: Nat Rev Immunol. 2012 Jul 25;12(8):570–580. doi: 10.1038/nri3261

Figure 1. The spectrum of autoimmune and autoinflammatory diseases.

Figure 1

Polygeneic diseases are boxed in green and menedelian disorders boxed in red. The horizontal axis depicts the range of organ-specfic vs. systemic disease, and the vertical axis, the degree of involvement of the parts of the immune system in immunopathology: innate (autoinflammatory, bottom) vs. adaptive (autoimmune, top).