Figure 1. Pre-Treatment (Post-Challenge) and Post-Treatment Mean PA levels in Sera from Study 1 Rabbits.

New Zealand white rabbits were exposed to 200×LD₅₀ doses of aerosolized B. anthracis spores and serum collected at different time points Post-Challenge (A) and Post-Infusion (B) was tested by electro-chemiluminiscence (ECL) assay for detection and quantitation of B. anthracis protective antigen (PA). Animals received combination treatment with Placebo+ levofloxacin or AIGIV + levofloxacin at 30, 36, 48 and 60 hours post-exposure. AIGIV was given IV as a slow infusion at 15 U/kg of body weight and levofloxacin at 50 mg/kg given orally once a day for 3 days. PI = Post-Infusion PC = Post-Challenge.