Table 1. Summary of mean time to death and survival of rabbits in two sequential combination treatment studies.
| 1A Study 1 | ||||||
| Treatment Time | Treatment | No. Exposed | No. Survived/No. Treated | Survival Rate1 (95% Confidence Interval) | Median Time to Death (hours) | p-value Pairwise Log- Rank Test2 |
| Control | None | 8 | 0/8 | 0.00 (0.00, 0.37) | 99.72 | - |
| 30 hours | Placebo+Levofloxacin | 8 | 8/8 | 1.00 (0.63, 1.00) | - | 1.0000 |
| AIGIV+Levofloxacin | 8 | 7/8 | 0.88 (0.47, 1.00) | - | ||
| 36 hours | Placebo+Levofloxacin | 8 | 8/8 | 1.00 (0.63, 1.00) | - | NA |
| AIGIV+Levofloxacin | 8 | 7/73 | 1.00 (0.59, 1.00) | - | ||
| 48 hours | Placebo+Levofloxacin | 8 | 8/8 | 1.00 (0.63, 1.00) | - | NA |
| AIGIV+Levofloxacin | 8 | 8/8 | 1.00 (0.63, 1.00) | - | ||
| 60 hours | Placebo+Levofloxacin | 8 | 7/8 | 0.88 (0.47, 1.00) | - | 1.0000 |
| AIGIV+Levofloxacin | 8 | 6/8 | 0.75 (0.35, 0.97) | - | ||
1
Survival rates for each group at day 30 post exposure.
2
Time-to-death and overall survival rates between groups by pairwise Log-rank test. NA- Log-rank test was not possible due to no deaths occurred in either group.
3
A total of 9 animals were exposed to anthrax spores but two were excluded from survival analysis due to death related to gavage error. - Not determined due to lack of sufficient number of deaths.
4
Survival rates for each group at day 32 post exposure.
5
Comparing overall-survival between the groups. *Two animals from 72 hours and one animal from 84 hours group were non bacteremic at the time of treatment.