Table 2. Effect of combination treatment on incidence of bacteremia and toxemia in study 1.
Bacteremia | ||||
Treatment Time | Treatment* | Time to Onset of Bacteremia (hours) Geometric Mean (Min, Max) | Bacteremia Incidence** No. Positive/No. Animals (%) | |
Pre-Treatment | Post-Treatment** | |||
Control | None | 29.49 (22.00.39.52) | 8/8 (100%) | NA |
30 hours | Placebo+Levofloxacin | 26.11 (22.35, 31.55) | 7/8 (88%) | 0/8 (0%) |
AIGIV+Levofloxacin | 27.36 (23.00,31.47) | 8/8 (100%) | 2/8 (25%) | |
36 hours | Placebo+Levofloxacin | 28.99 (23.47, 34.40) | 4/8 (50%) | 0/8 (0%) |
AIGIV+Levofloxacin | 23.94 (21.30, 27.47) | 5/7 (71%) | 0/7 (0%) | |
48 hours | Placebo+Levofloxacin | 27.29 (22.18, 42.18) | 7/8 (88%) | 1/8 (13%) |
AIGIV+Levofloxacin | 28.11 (25.02, 31.52) | 6/8 (75%) | 0/8 (0%) | |
60 hours | Placebo+Levofloxacin | 29.57 (25.23,34.03) | 8/8 (100%) | 0/8 (0%) |
AIGIV+Levofloxacin | 29.93 (23.93, 35.07) | 8/8 (100%) | 0/8 (0%) | |
Total | 27.96 (21.30,42.18) | 61/71 (86%) | 3/63 (5%) | |
Placebo +Levofloxacin | - | 26/32 (81%) | 1/32 (3%) | |
AIGIV +Levofloxacin | - | 27/31 (87%) | 2/31 (6%) |
NA- not applicable as animals were not treated.** data from all time points up to treatment (pre-treatment) and all time points post-treatment were combined for overall incidence.