. 2014 Sep 16;9(9):e106393. doi: 10.1371/journal.pone.0106393

Table 3. Effect of combination treatment on incidence of bacteremia in study 2.

Treatment Time	Treatment*	Time to Onset of Bacteremia (hours)Geometric Mean (Min Max)^a	Bacteremia Incidence (No. Positive/No. Animals (%))
			Pre- Treatment	Post-Treatment^**
				24 hours	Day 3	Day 5	Terminal
60 hours	Placebo+ Levofloxacin	30.22 (23.37,36.57)	10/10 (100%)	1/9 (11.1%)	0/9 (0%)	0/9 (0%)	0/1 (0%)
	AIGIV +Levofloxacin	29.21 (23.60,49.55)	8/8 (100%)	0/8 (0%)^b	0/8 (0%) ^b	1/8 (13%) ^b	—
72 hours	Placebo+ Levofloxacin	27.87 (20.48,49.13)	18/20 (90%)	0/15 (0%)	0/12 (0%)	1/11 (9%)	0/9 (0%)
	AIGIV +Levofloxacin	32.13 (21.20,73.27)	23/23 (100%)	0/22 (0%) ^b	0/19 (0%) ^b	0/16 (0%) ^b	0/8 (0%) ^b
84 hours	Placebo+ Levofloxacin	29.55 (21.20,37.70)	8/9 (88.9%)	0/8 (0%)	0/5 (0%)	0/3 (0%)	1/6 (17%)
	AIGIV +Levofloxacin	35.77 (21.40.78.58)	10/10 (100%)	1/9 (11.1%) ^b	0/5 (0%) ^b	0/4 (0%) ^b	0/5 (0%) ^b
96 hours	Placebo+ Levofloxacin	38.38 (22.32,72.53)	8/8 (100%)	1/5 (20%)	0/3 (0%)	0/2 (0%)	1/5 (20%)
	AIGIV +Levofloxacin	37.88 (19.50,85.37)	7/7 (100%)	1/6 (16.7%) ^b	0/5 (0%) ^b	0/5 (0%) ^b	0/2 (0%) ^b

The overall mean onset time for all groups is 31.54 (19.50, 85.37).

Pairwise comparison Fisher's exact test p>0.05 AIGIV+levofloxacin vs. placebo+levofloxacin.

— No animal died.

**Post-treatment blood collection was relative to the end of infusion (after the first levofloxacin dose).