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. Author manuscript; available in PMC: 2014 Sep 16.
Published in final edited form as: Glia. 2013 Apr 2;61(7):1029–1040. doi: 10.1002/glia.22491

Fig. 6. Purinergic signaling induces GDNF expression in explants and Schwann cells through PKD activation.

Fig. 6

A) Induction of GDNF expression by injury in ex vivo nerve segments is reduced by the presence of apyrase (APY), an ectonucleotidase that degrades ATP and ADP.

B) ATP stimulates GDNF expression by Schwann cells, an effect that is blocked by apyrase (APY).

C) Inhibition of PKD by CRT0066101 (CRT) blocks the ATP-mediated increases in GDNF expression by Schwann cells.