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. Author manuscript; available in PMC: 2014 Sep 16.
Published in final edited form as: Science. 2012 Sep 14;337(6100):1357–1360. doi: 10.1126/science.1220845

Fig. 1.

Fig. 1

PFC-dependent behaviors and mPFC oligodendrocytes are altered by juvenile isolation. (A and B) Mice reared in isolation starting at P21 (IS), by P50 show alterations in social interactions (A) and working memory (B) compared with mice in regular (RE) or enriched environment (EE) (n = 16 mice per group). (C to G) Rearing environment does not influence mPFC oligodendrocyte density by P65 (n = 3 mice per group), but social isolation results in mPFC oligodendrocytes with simpler morphology (cells per condition: IS = 12, RE = 16, EE = 16). (H) P21 to P65 isolation reduces mPFC MBP and MAG expression. AU = arbitrary units; (mice per group: IS = 8, RE = 8, EE = 4). (I to J) P21 to P65 isolation leads to reduced mPFC myelin thickness (n = 3 per group) without changes in axon diameters (450 axons per group). *P < 0.05, **P < 0.01, ***P < 0.001. Error bars, SEM.