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. Author manuscript; available in PMC: 2014 Sep 17.
Published in final edited form as: Immunity. 2013 Jan 24;38(1):1–3. doi: 10.1016/j.immuni.2013.01.005

Figure 1. Role of CD70-CD27 Signaling in the Control of Th17 Cell Differentiation.

Figure 1

CD70 is induced in activated DCs and signals through CD27 on activated CD4+ T cells, leading to enhanced phosphorylation of JNK via TRAF2 or TRAF5 signaling. Activation of JNK antagonizes RORγt-induced IL-17, IL-17F, and CCR6 expression via transcriptional suppression or through epigenetically silencing the Il17a locus; this then limits overactivation of Th17-cell-mediated responses and associated autoimmunity and might help to maintain homeostasis of the gut-associated immune system (Nolte et al., 2009).