Table 1.

List of parameters from NH₃ distributed model

	Values	Units	Definition
Model inputs
Fp	*	mL/g/minute	Flow of 13N containing plasma
PSn; PSmi	0.2+ 1.9 .Fp† 0.04 + 0.1 Fp†	mL/g/minute	Permeability surface area product for NH3 and glutamine, respectively
G	*	mL/g/minute	Regional consumption of NH3 into glutamine and glutamate
DcavDpDm	lE–5§	mm2/s	Diffusion coefficient in blood, plasma, and myocyte, respectively
Vcav, Vp, Vm	*, 0.06§, 0.56§	mL/g	Volumes, Vcav between input cavity and blood tissue unit, Vp capillary plasma, and in myocytes, Vm, respectively
L	0.8§	mm	Regional capillary length
Fma	0.4†	-	Fraction of consumed NH3 sequestered as glutamate
spill	*	mL/g	Spillover from LV cavity to myocardium
Cin (t)		mmoI/mL	Input function time-activity curve
Model dependent variables
t	[0, 180]	Seconds	Time from start of input function
X	[0,L]	mm	Distance along capillary length
z	[0, Lz	mm	Distance from input function ROI to myocardium
Model outputs
CNcav(t,z); CNp(t,x); CN,m(t,x)		mmoI/mL	Concentration of NH3 in cavity, plasma, and myocyte, respectively
CMI,P(tx); CMIm(tx)		mmoI/mL	Concentration of glutamine in plasma and myocyte, respectively
CMA,m(tx)		mmoI/mL	Concentration of glutamate in myocyte
Qtot(t)		mmoI/mL	Total residue signal of 13N in myocyte (fit to myocardial TAC)

^*Value is estimated.

^†Value/relationship derived from training data sets.

^§Value/relationship from.^25–27