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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: J Invest Dermatol. 2014 Apr 22;134(10):2562–2569. doi: 10.1038/jid.2014.201

Figure 3. Elevated IL-12 production in K14E7 compared to wild type skin is dispensable for IFN-γ production.

Figure 3

a IL-12p70 and IL-12/23p40 concentrations in supernatants of C57BL/6 and K14E7 skin explants following 20 h of culture (n=4 mice per group). Results are representative of at least 2 independent experiments. b,c IFN-γ concentrations in supernatants of K14E7 skin explants cultured with 10 μg/mL isotype or (b) anti-IL12/23p40 antibody or (c) anti-IL-23p19 antibody (n=6 mice) for 40 h. Results for individual mice obtained in 2 independent experiments are shown. d IFN-γ concentrations in the supernatants of K14E7 transgenic IL-12p40 heterozygous, IL-12p40 deficient, IFN-γ heterozygous (n=6-7 mice each) or IFN-γ deficient (n=3) skin explants (n.d.: below detection limit). Results were obtained in 2 independent experiments. Bars indicate means±SEM.