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. 2014 Sep 16;12(9):e1001951. doi: 10.1371/journal.pbio.1001951

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© 2014 Regoes et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Frequencies of the HLA-B genotypes in our study population of 923 individuals. Approximately half of the genotypes are represented by only one individual. (B) Visualizing the random effect of the mixed effect modeling approach. Estimated tolerance curves for each HLA-B genotype, based on best linear unbiased predictions, are shown. We estimated a mean tolerance parameter (red curve), and a deviation of the random effects, , of (see Text S1).

Inline graphic — (A) Frequencies of the HLA-B genotypes in our study population of 923 individuals. Approximately half of the genotypes are represented by only one individual. (B) Visualizing the random effect of the mixed effect modeling approach. Estimated tolerance curves for each HLA-B genotype, based on best linear unbiased predictions, are shown. We estimated a mean tolerance parameter (red curve), and a deviation of the random effects, , of (see Text S1).