Table 2.
Echocardiographic Characteristics based on Early Regression of Severe LVH after TAVR
| TAVR A (RCT + NRCA) n=690 |
|||
|---|---|---|---|
| Greater LVMi Regression (n=344) |
Lesser LVMi Regression (n=346) |
p-value | |
| Baseline Echo Variables | |||
| LVMi (g/m2) | 171 ± 32 | 162 ± 28 | <0.001 |
| Ejection fraction (%) | 50 ± 13 | 49 ± 14 | 0.13 |
| Midwall fractional shortening (%) | 13.5 ± 8.0 | 11.3 ± 6.8 | <0.001 |
| Stroke Volume Index (ml/m2) | 38 ± 11 | 37 ± 11 | 0.17 |
| LV end-diastolic dimension (cm) | 4.68 ± 0.77 | 4.72 ± 0.76 | 0.40 |
| LV end-systolic dimension (cm) | 3.46 ± 0.96 | 3.53 ± 0.94 | 0.34 |
| LV posterior wall dimension (cm) | 1.28 ± 0.28 | 1.23 ± 0.26 | 0.02 |
| LV septal wall dimension (cm) | 1.76 ± 0.28 | 1.72 ± 0.33 | 0.09 |
| Relative wall thickness (PWT only) | 0.57 ± 0.19 | 0.54 ± 0.18 | 0.04 |
| Relative wall thickness (PWT and SWT) | 0.68 ± 0.19 | 0.65 ± 0.19 | 0.08 |
| LVOT dimension (cm) | 2.02 ± 0.19 | 2.03 ± 0.19 | 0.46 |
| AVA index (cm2/m2) | 0.37 ± 0.10 | 0.37 ± 0.11 | 0.67 |
| AV mean gradient (mmHg) | 47 ± 15 | 44 ± 15 | 0.057 |
| Moderate and severe total AR | 12.8% | 10.2% | 0.28 |
| Moderate and severe MR | 24.9% | 22.4% | 0.46 |
| Post-TAVR Echo Variables (30 days) | |||
| LVMi (g/m2) | 132 ± 27 | 164 ± 32 | <0.001 |
| Ejection fraction (%) | 53 ± 12 | 52 ± 12 | 0.34 |
| Midwall fractional shortening (%) | 13.8 ± 8.2 | 13.2 ± 6.9 | 0.27 |
| Stroke Volume Index (ml/m2) | 39 ± 12 | 39 ± 12 | 0.75 |
| LV end-diastolic dimension (cm) | 4.58 ± 0.79 | 4.80 ± 0.81 | <0.001 |
| LV end-systolic dimension (cm) | 3.32 ± 0.94 | 3.51 ± 0.93 | 0.006 |
| LV posterior wall dimension (cm) | 1.10 ± 0.23 | 1.22 ± 0.27 | <0.001 |
| LV septal wall dimension (cm) | 1.52 ± 0.27 | 1.69 ± 0.32 | <0.001 |
| Relative wall thickness (PWT only) | 0.50 ± 0.16 | 0.53 ± 0.18 | 0.01 |
| Relative wall thickness (PWT and SWT) | 0.60 ± 0.17 | 0.63 ± 0.19 | 0.008 |
| EOA index (cm2/m2) | 0.99 ± 0.29 | 0.96 ± 0.29 | 0.10 |
| PPM (moderate and severe) | 33.5% | 41.3% | 0.04 |
| PPM (severe) | 10.0% | 12.7% | 0.27 |
| AV mean gradient (mmHg) | 9 ± 4 | 10 ± 5 | 0.10 |
| Mild total AR | 49.4% | 52.3% | 0.45 |
| Moderate and severe total AR | 12.5% | 14.2% | 0.52 |
| Moderate and severe MR | 19.5% | 21.1% | 0.61 |
Greater vs. lesser LVMi regression defined by sex-specific median % change in LVMi from baseline to 30 days post-TAVR. Moderate PPM = EOA index 0.65–0.85 cm2/m2. Severe PPM = EOA index <0.65 cm2/m2.
Abbreviations: PWT, posterior wall thickness; SWT, septal wall thickness; EOA, effective orifice area; PPM, prosthesis-patient mismatch; AV, aortic valve; AR, aortic regurgitation; MR, mitral regurgitation; other abbreviations as in Table 1.