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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: JACC Cardiovasc Interv. 2014 Jun;7(6):662–673. doi: 10.1016/j.jcin.2014.02.011

Table 5.

Sub-Group Analyses for Repeat Hospitalizations

Repeat Hospitalizations Greater
LVMi
Regression
% (no.)
Lesser LVMi
Regression
% (no.)
Hazard Ratio (95%
CI)
p-value
Overall population n=344 n=346
Repeat hospitalizations 9.5% (30) 18.5% (59) 0.50 [0.32, 0.78] 0.002
Trial Group p for interaction = 0.16
  TAVR Cohort A RCT n=63 n=74
13.8% (8) 16.3% (11) 0.90 [0.36, 2.24] 0.82
  TAVR Cohort A NRCA n=281 n=272
8.6% (22) 19.0% (48) 0.43 [0.26, 0.71] 0.0007
Access Route p for interaction = 0.54
  Transfemoral n=179 n=197
8.9% (15) 15.4% (28) 0.57 [0.30, 1.06] 0.07
  Transapical n=165 n=149
10.1% (15) 22.6% (31) 0.43 [0.23, 0.80] 0.006
Sex p for interaction = 0.46
  Male n=151 n=152
13.5% (19) 23.3% (32) 0.57 [0.32, 1.01] 0.05
  Female n=193 n=194
6.2% (11) 15.0% (27) 0.41 [0.20, 0.82] 0.009
Relative wall thickness p for interaction = 0.12
  RWT ≥ median n=186 n=159
11.0% (19) 15.5% (23) 0.71 [0.39, 1.30] 0.26
  RWT < median n=158 n=187
7.5% (11) 21.0% (36) 0.35 [0.18,0.68] 0.001
LV end-diastolic dimension p for interaction = 0.40
  LVEDD ≥ median n=166 n=177
14.4% (22) 24.5% (40) 0.58 [0.35, 0.98] 0.04
  LVEDD < median n=178 n=169
4.9% (8) 12.2% (19) 0.38 [0.17, 0.88] 0.02
Ejection fraction p for interaction = 0.14
  EF ≥50% n=216 n=195
9.6% (19) 13.6% (24) 0.71 [0.39, 1.30] 0.27
  EF <50% n=127 n=151
9.3% (11) 24.8% (35) 0.36 [0.18, 0.71] 0.002
Midwall fractional shortening p for interaction = 0.48
  MFS ≥ median n=177 n=149
8.5% (14) 19.0% (26) 0.45 [0.23,0.86] 0.01
  MFS < median n=141 n=185
10.8% (14) 17.0% (29) 0.62 [0.33, 1.18] 0.14
Stroke volume index p for interaction = 0.23
  SVi ≥35 raL/m2 n=194 n=175
7.3% (13) 18.0% (29) 0.39 [0.20, 0.75] 0.003
  SVi <35 mL/m2 n=144 n=165
13.0% (17) 18.9% (29) 0.68 [0.37, 1.24] 0.2
Mean gradient p for interaction = 0.28
  MG ≥40 mmHg n=216 n=191
6.4% (13) 15.3% (27) 0.40 [0.21, 0.78] 0.005
  MG <40 mmHg n=122 n=150
14.6% (16) 22.5% (31) 0.66 [0.36, 1.22] 0.18
30 day paravalvular AR p for interaction = 0.18
  Mod/severe paravalvular AR n=38 n=44
22.4% (8) 24.6% (10) 0.92 [0.36, 2.32] 0.85
  No/trace/mild paravalvular AR n=306 n=299
7.8% (22) 17.4% (48) 0.44 [0.27, 0.73] 0.001

Cox proportional hazards models were used to evaluate the hazard ratios for patients in each subgroup for the outcome of repeat hospitalizations and the interaction between each sub-group and LVMi regression (greater vs. lesser regression from baseline to 30 days post-TAVR based on sex-specific median % change in LVMI) for repeat hospitalizations.