Table 6.
Predictors of Repeat Hospitalization (30 Days to 1 Year) Based on Early Regression of Severe LVH after TAVR
| Variable | Hazard ratio (95% CI) | p-value |
|---|---|---|
| Model 1 – Clinical Model | ||
| Greater Early LVMi Regression (baseline to 30 days) | 0.52 (0.33, 0.81) | 0.004 |
| Age (per year) | 0.98 (0.95, 1.01) | 0.12 |
| Male sex | 1.37 (0.87, 2.17) | 0.18 |
| Baseline LVMi (per 1 g/m2 increase) | 1.00 (1.00, 1.01) | 0.39 |
| Major arrhythmia | 1.91 (1.23, 2.96) | 0.004 |
| Prior PCI | 1.70 (1.11, 2.59) | 0.01 |
| Smoking | 1.77 (1.14, 2.76) | 0.01 |
| Model 2 – Clinical and Echocardiographic Model | ||
| Greater Early LVMi Regression (baseline to 30 days) | 0.53 (0.34, 0.84) | 0.007 |
| Age (per year) | 0.97 (0.94, 1.00) | 0.055 |
| Male sex | 1.32 (0.83, 2.10) | 0.23 |
| Baseline LVMi (per 1 g/m2 increase) | 1.00 (1.00, 1.01) | 0.35 |
| Major arrhythmia | 1.74 (1.12, 2.71) | 0.01 |
| Prior PCI | 1.52 (0.99, 2.35) | 0.06 |
| Smoking | 1.81 (1.16, 2.82) | 0.009 |
| Baseline mean gradient (per 1 mmHg increase) | 0.98 (0.96, 1.00) | 0.02 |
| Moderate/severe AR at 30 days | 1.59 (0.99, 2.57) | 0.06 |
Cox PH models evaluating whether greater early left ventricular mass index (LVMi) from baseline to 30 days post-TAVR (based on sex-specific median % change in LVMi) is an independent predictor of the clinical endpoint of repeat hospitalization from 30–365 days.
Model 1: Selection model including age, sex, baseline LVMi, and LVMi regression (greater vs. lesser change in LVMi from baseline to 30 days) (forced variables) and other variables selected from among the baseline clinical variables and clinical events from 0–30 days (myocardial infarction, any stroke, major vascular complication, major bleeding, renal failure requiring dialysis) that have a significant (p≤0.10) univariable relationship with the clinical endpoint of repeat hospitalization from 30–365 days (Supplemental Table 1).
Model 2: Selection model including the same variables as Model 1 in addition to baseline or 30 day echo variables that have a significant (p≤0.10) univariable relationship with the clinical endpoint of repeat hospitalization from 30–365 days (Supplemental Table 1). Echocardiographic variables were excluded if they were a part of the calculation of LVMi (LV cavity dimensions and wall thickness).
Abbreviations: LVMi, left ventricular mass index; PCI, percutaneous coronary intervention; AR, aortic regurgitation.