Table 3. EC50, IC50 and therapeutic index for seven cherry-picked compounds.
Firefly Luciferase | Cytotoxicity | |||
Compound ID | EC50 (µM) | Fold-induction | IC50 (µM) | Therapeutic Index |
1 | 1.4 | 8.6 | >100 | >100 |
7 | 5.9 | 6.5 | 87.6 | 15 |
42 | 9.8 | 5.2 | >100 | >100 |
87 | 49.3 | 9.6 | >100 | >100 |
125 | 5.7 | 7.0 | 35.0 | 6 |
157 | 30.0 | 9.5 | >100 | >100 |
208 | 14.3 | 10.1 | 24.3 | 2 |
>100: Less than 10% or no cytotoxicity up to 100 µM tested.