Skip to main content
. 2014 Sep 16;9(9):e107230. doi: 10.1371/journal.pone.0107230

Table 3. KEGG pathway mapping.

Module cluster → 8 1 1 11 20 20 9 9 Injury indicator
KEGG pathway ↓ Module → 23 3 1 27 40 41 24 25
Biosynthesis of unsaturated fatty acids Albumin increase & Eosinophilia
Butanoate metabolism
Fatty acid metabolism
Peroxisome
Propanoate metabolism
Valine, leucine and isoleucine degradation
Drug metabolism - CYP P450 Spleen weight decrease
Metabolism of xenobiotics by CYP P450
Glutathione metabolism
Glutathione metabolism Periportal lipid accumulation
Proteasome
Natural killer cell mediated cytotoxicity Periportal fibrosis
Regulation of actin cytoskeleton
Leukocyte transendothelial migration
Phagosome
Pyruvate metabolism Alkaline phosphatase & Liver weight decrease
Pyruvate metabolism Basophil increase

Pathways are at left, injury indicators are at right, and connecting gene co-expression modules are in the middle. Pathways are included only if they are associated with absolute module activation scores, Inline graphic, greater than 1.5, if they have Bonferroni-corrected p-values less than 0.05, and if there are at least six hits from the module in the pathway.