Table 4. Gene signatures for Periportal lipid accumulation.
Module | Activation | Gene symbol | Gene name | Rat Genome Database terms[56] |
30 | ↑ | Gpd1l | Glycerol-3-phosphate dehydrogenase 1-like | Metabolic process; NADH metabolic process; negative regulation of peptidyl-serine phosphorylation |
29 | ↑ | Cndp2 | CNDP dipeptidase 2 (metallopeptidase M20 family) | Proteolysis |
27 | ↑ | Psma5 | Proteasome (prosome, macropain) subunit, alpha type 5 | Ubiquitin-dependent protein catabolic process; ubiquitin/proteasome degradation pathway |
1 | ↑ | Atpif1 | ATPase inhibitory factor 1 | Erythrocyte differentiation; heme biosynthetic process; negative regulation of endothelial cell proliferation |
19,15 | ↓ | Slc22a8 | Solute carrier family 22 (organic anion transporter), member 8 | Glutathione transport; quaternary ammonium group transport; response to methotrexate |
8-11 | ↓ | Serpina6 | Serine (or cysteine) peptidase inhibitor, clade A, member 6 (secreted)[57] | Glucocorticoid metabolic process |
13 | ↓ | Gulo * | Gulonolactone (L-) oxidase* | L-ascorbic acid biosynthetic process |
6 | ↓ | Nrep | Neuronal regeneration related protein | Axon regeneration; regulation of neuron differentiation; regulation of transforming growth factor beta receptor signaling pathway |
20 | ↓ | Dhrs7 | Dehydrogenase/reductase (SDR family) member 7 (secreted)[57] | Encodes a protein that exhibits oxidoreductase activity |
12 | ↓ | Car3 * [58] | Carbonic anhydrase 3 (secreted)[57] | Response to ethanol; response to oxidative stress |
*Listed as having a curated association with liver injury in the Comparative Toxicogenomics Database [20].