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. 2014 Sep 16;9(9):e107230. doi: 10.1371/journal.pone.0107230

Table 4. Gene signatures for Periportal lipid accumulation.

Module Activation Gene symbol Gene name Rat Genome Database terms[56]
30 Gpd1l Glycerol-3-phosphate dehydrogenase 1-like Metabolic process; NADH metabolic process; negative regulation of peptidyl-serine phosphorylation
29 Cndp2 CNDP dipeptidase 2 (metallopeptidase M20 family) Proteolysis
27 Psma5 Proteasome (prosome, macropain) subunit, alpha type 5 Ubiquitin-dependent protein catabolic process; ubiquitin/proteasome degradation pathway
1 Atpif1 ATPase inhibitory factor 1 Erythrocyte differentiation; heme biosynthetic process; negative regulation of endothelial cell proliferation
19,15 Slc22a8 Solute carrier family 22 (organic anion transporter), member 8 Glutathione transport; quaternary ammonium group transport; response to methotrexate
8-11 Serpina6 Serine (or cysteine) peptidase inhibitor, clade A, member 6 (secreted)[57] Glucocorticoid metabolic process
13 Gulo * Gulonolactone (L-) oxidase* L-ascorbic acid biosynthetic process
6 Nrep Neuronal regeneration related protein Axon regeneration; regulation of neuron differentiation; regulation of transforming growth factor beta receptor signaling pathway
20 Dhrs7 Dehydrogenase/reductase (SDR family) member 7 (secreted)[57] Encodes a protein that exhibits oxidoreductase activity
12 Car3 * [58] Carbonic anhydrase 3 (secreted)[57] Response to ethanol; response to oxidative stress

*Listed as having a curated association with liver injury in the Comparative Toxicogenomics Database [20].