Table 1.
Proportion of subjects with diarrhea, incubation period, stool output and episode duration among 30 volunteers experimentally infected with ETEC strain TW10598 (STh LT-CS2 CS3 CS21; O6:K15:H16)
| Target dose (CFU) | No. of volunteers | No. with diarrhea | Attack risk | Median severity | Mean incubation period, hours (range) | Mean 24 hrs maximum stool output, grams (range) | Mean whole episode stool output, grams (range) | Mean episode duration, hrs (range) | Mean 24 hrs maximum stool output, count (range) |
|---|---|---|---|---|---|---|---|---|---|
| 1 × 106 | 3 | 2 | 67% | Mild-Moderate | 60 (48–72) | 416 (330–502) | 613 (510–717) | 37 (25–48) | 2 (2–2) |
| 1 × 107 | 8 | 5 | 63% | Moderate | 37 (9–70) | 676 (407–1352) | 877 (407–1842) | 38 (6–72) | 5 (3–9) |
| 1 × 108 | 7 | 6 | 86% | Moderate-Severe | 38 (13–78) | 965 (318–1790) | 1466 (450–3608) | 46 (18–78) | 6.5 (3–13) |
| 1 × 109 | 12 | 10 | 83% | Moderate | 30 (10–57) | 538 (295–918) | 687 (358–1315) | 33 (1–106) | 4.2 (1–9) |