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. 2014 Sep 17;4:6226. doi: 10.1038/srep06226

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(A), Treatment with SAHA results in a significant suppression of xCT-expression, which was detected by real-time RT-PCR. (B), The same probes were then utilized to analyze the factors Nrf2 and Keap1 through real-time RT-PCR. SAHA reduces significantly the expression of Keap1, while Nrf2 is unaffected. (C), The expression of sestrin2 is marginally but significantly reduced after SAHA treatment, while the xCT regulating transcription factor ATF4 is reduced in its expression following SAHA treatment. Since changes in sestrin2 expression were both weak and dosage-independent, it can be assumed that SAHA does not regulate xCT expression mainly through the Sestrin2/Keap1/Nrf2 axis. Statistical significance was calculated with the Student's t-test (mean ± s.d., *P < 0.05, n ≥ 8 per group).