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. 2014 Aug 11;25(9):1664–1677. doi: 10.1021/bc5002856

Figure 6.

Figure 6

PXR competitive-binding activities of 10 (vinblastine), 12 (deacetyl vinblastine), 13 (catharanthine), 15 (catharanthinic acid), 14 (vindoline), and 16 (deacetyl vindoline) in the 4 (BODIPY FL vinblastine)-based PXR binding assay. (A) Representative inhibitory activities of individual chemicals along with negative control DMSO and positive control 1 (TO901317, 10 μM). (B) Dose–response curves of 1 (TO901317), 10 (vinblastine), 15 (catharanthinic acid), 14 (vindoline), and 16 (deacetyl vindoline).