Table 2.

Effects of SOCS2 on bone development in juvenile and adult female mice. Data are presented as mean±s.e.m. (n=6)

	6 weeks		17 weeks
WT	Socs2 −/−	WT	Socs2 −/−
Growth
Weight (g)	16.3±0.62	19.3±0.4†	26.2±0.91	31.3±0.99†
Weight gain (g/day)	0.14±0.04	0.21±0.04	0.06±0.037	0.02±0.05
Trabecular
BV/TV (%)	9.7±0.25	12.7±0.88†	8.0±0.38	9.9±0.52*
Tb.N (1/mm)	2.4±0.09	2.7±0.13*	1.6±0.10	1.4±0.09
Tb.Th (mm)	0.04±0.001	0.05±0.002†	0.05±0.002	0.07±0.001‡
Tb.Sp (mm)	0.22±0.01	0.23±0.01	0.28±0.01	0.33±0.03*
SMI	2.0±0.04	2.0±0.05	2.4±0.28	2.3±0.10
BMD (g/cm3)	1.48±0.006	1.47±0.01	1.56±0.01	1.57±0.01
Cortical
Tt.Ar (mm2)	0.6±0.02	0.7±0.01†	0.7±0.02	0.8±0.04*
Ct.Ar (mm2)	0.4±0.01	0.5±0.01	0.6±0.004	0.6±0.02
Ma.Ar (mm2)	0.19±0.008	0.26±0.008‡	0.16±0.008	0.12±0.039
Ct.Th (mm)	0.21±0.005	0.20±0.002	0.26±0.009	0.27±0.007
J (mm4)	0.05±0.003	0.07±0.003*	0.08±0.007	0.09±0.007*
BMD (g/cm3)	1.34±0.007	1.32±0.006	1.44±0.005	1.41±0.006†
Biomechanical
Failure load (N)	5.6±0.51	5.7±0.45	9.3±0.54	10.0±0.90
Work to failure (mJ)	2.4±0.31	2.0±0.22	3.0±0.27	3.0±0.26
Load to maximum stiffness (N)	2.7±0.35	2.1±0.27	5.5±0.8	5.7±0.5
Maximum stiffness (N/mm)	11.1±1.32	12.5±0.95	18.2±1.47	22.7±3.42

For trabecular data BV/TV, bone volume/tissue volume; Tb.N, trabecular number; Tb.Th, trabecular thickness; Tb.Sp, trabecular separation; SMI, structural model index. For cortical data Tt.Ar, total tissue area; Ct.Ar, cortical bone area; Ma.Ar, medullary area; Ct.Th, cortical thickness; J, polar moment of inertia. Significance from age-matched WT mice is denoted by *P<0.05, ^† P<0.01, ^‡ P<0.001.