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. 2014 Sep 11;7:1583–1591. doi: 10.2147/OTT.S67624

Figure 4.

Figure 4

K-Ras is a direct target of miR-206. (A) MiR-206 binding sites in K-Ras 3′ UTR. K-Ras–mut indicates the K-Ras 3′ UTR with mutation in miR-206 binding sites. (B) The Western blot showed that transfection of miR-206 decreased K-Ras protein expression. (C) Relative luciferase assay comparing the pGL3–K-Ras and pGL3–K-Ras–mut vectors in Tca8113 cells. Firefly luciferase activity was normalized to renilla luciferase activity. *P<0.05.

Abbreviations: hsa-miR-206, human microRNA-206; UTR, untranslated region; WT, wild type; Mut, mutation.