Table 3.
Primary and secondary outcomes of the study.
| Parameter | N = 88 patients and 98 reoperations |
|---|---|
| Reeplorations, mean ±SD (range) | 1.18±0.58 (1–4) |
|
| |
| Surgical approach, No. (%) | |
| Unilateral | 64 (66.3) |
| Bilateral | 34 (34.7) |
|
| |
| Medistinal exploration, No. (%) | |
| Transcervical | 16 (18.2) |
| Sternotomy | 3 (3.4) |
|
| |
| Localization of diseased parathyroid tissue missed at initial exploration, No. (%) | |
| Eutopic | 49 (55.7) |
| Ectopic | |
| In the neck | 20 (22.7) |
| Mediastinal | 19 (21.6) |
|
| |
| Diseased parathyroid glands removed, No. (%) | |
| 1 | 77 (87.5) |
| 2 | 6 (6.8) |
| 2 and a half | 4 (4.5) |
| 3 | 1 (1.1) |
|
| |
| Use of intraoperative adjuncts, No. (%) | |
| IOPTH | 52 (53.1) |
| Gamma-probe | 27 (27.6) |
| Frozen-section | 11 (12.5) |
|
| |
| Operative time, mean (range) | 93.6 (35.0–180.0) |
|
| |
| Pathological report, No. (%) | |
| Solitary parathyroid adenoma | 60 (68.2) |
| Multiple parathyroid disease | 25 (28.4) |
| Double adenoma | 6 (6.8) |
| Non-MEN associated parathyroid hyperplasia | 9 (10.2) |
| MEN 1 | |
| pHPT | 4 (44.4) |
| rHPT | 5 (55.6) |
| MEN 2A | |
| pHPT | 1 (1.1) |
| rHPT | 0 (0) |
| Parathyroid cancer | 3 (3.4) |
|
| |
| Weight of diseased parathyroid/s, g (range) | 1.37 (0.36–30.2) |
|
| |
| Cure rate, No. (%) | |
| Total | 83 (94.3) |
| pHPT | 53 (93.0) |
| rHPT | 30 (96.8) |
|
| |
| Serum calcium on postoperative day 2, mean (range); mmol/l | 2.18 (1.61–3.1)* |
|
| |
| Short-term morbidity, No. (%) | |
| Transient unilateral RLN injury | 10 (11.4) |
| Postoperative hypocalcemia | 72 (81.8) |
| Bleeding | 0 (0.0) |
| Wound infection | 0 (0.0) |
| Others | 0 (0.0) |
|
| |
| Long-term morbidity, No. (%) | |
| Permanent unilateral RLN injury | 6 (6.8) |
| Permanent bilateral RLN injury | 1 (1.1)** |
| Permanent hypoparathyroidism | 12 (13.6) |
|
| |
| Need for delayed parathyroid tissue autotransplantation, No. (%) | 0 (0.0) |
SD – standard deviation; IOPTH – intraoperative iPTH assay; MEN – multiple endocrine neoplasia; pHPT – persistent primary hyperparathyroidism; rHPT – recurrent primary hyperparathyroidism; RLN – recurrent laryngeal nerve; (*) increased serum calcium was found in 5 patients with persistent disease following reexplorations; (**) bilateral RLN injury occurred in 1 patient with pre-reoperative unilateral RLN palsy.