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. 2014 Sep 17;8:290. doi: 10.3389/fnins.2014.00290

Figure 6.

Figure 6

Mean percent intact CTB (anterograde tracer), ERRβ (axon terminal label), and FluoroGold (FG; retrograde tracer) label shows respective loss of each tracer within age groups. Within-subjects' statistical analyses showed that there are no differences in the amount of each label in the DBA/2J-Gpnmb+ (D2G) control and 3-month old (mo.) pre-glaucomatous DBA/2J groups (Paired t-test: P = ns in all cases). Retinal retrograde (FG) label was significantly more intact than collicular anterograde CTB label in glaucomatous DBA/2J at 9–10 mo. (P = 0.03) and 11–12 mo. (P = 0.02). ERRβ label remained significantly more intact than FG label in DBA/2J mice at 9-10 mo. (P = 0.02) and 11–12 mo. (P = 0.005). There were no differences in the magnitude of intact label between CTB, ERRβ, and FG by 13-mo (P = ns). Asterisks and brackets indicate statistically significant differences between specific groups. Number of cases per group are shown in parentheses. Error bars show standard error of the mean for each group.