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. 2014 Sep 17;8:326. doi: 10.3389/fnbeh.2014.00326

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Copyright © 2014 Aimé, Palouzier-Paulignan, Salem, Al Koborssy, Garcia, Duchamp, Romestaing and Julliard.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Genotype effect on the dynamic response of [Gluc]_ECF in OB and cortex to glucose and insulin peripheral injections. Composite figures compiled from in vivo real time recordings of [Gluc]_ECF, performed simultaneously in OB (full line) and cortex (Ctx, dotted line) of lean fa/+ (A, B) and obese fa/fa rats (C, D) in fasted (A, C: Fast., blue) and satiated (B, D Sat., red) states. In fasted rats, glucose was injected in first (G. Inj1), and insulin in second (I. Inj2). The order of injections was reversed in satiated rats (I-Inj1, G-Inj2). For fasted (E) and satiated (F) rats, mixed ANOVA revealed a significant effect of genotype (in fasted rat ^# P < 0.01; in satiated rats ^### P < 0.0005), conditions (not shown) and brain areas (not shown). SS: steady State; G: glucose; I: insulin.