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. 2014 Sep 15;8:248. doi: 10.3389/fncel.2014.00248

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Copyright © 2014 Sun, Sun, Zhang, Cheng, Waqas, Yu, He, Xu, Wang, Wang, Yin, Chai and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Apoptosis-related gene expression in neomycin-treated WT mice. (A,B) mRNA expression of the anti-apoptotic genes Xiap (A1) and Xaf1 (A2) and the pro-apoptotic genes Casp3 (B1), Casp9 (B2), Diablo (B3), and Htra2 (B4) in the apical 50% and basal 50% of the cochleae in WT mice sacrificed 3 days after the last injection of neomycin or saline (control). Neomycin or saline was injected between P1 and P7 (Group 1), P8 and P14 (Group 2), P15 and P21 (Group 3), or P60 and P66 (Group 4). ^*p < 0.05, ^**p < 0.01 vs. control, n = 3.