Figure 4.

FMR1 methylation and FMRP are associated with FSIQ scores as measured by Stanford Binet-5, WISC, WAIS-III, Weschler, and WPPSI-III Standardized tests. Scatterplots show IQ scores (y-axis) as a function of percent methylation (x-axis) in PBMCs (A) and fibroblasts (B), demonstrating a significant correlation between lower IQ and greater percent of methylation in both cell types. Circles represent observed data and the solid line shows the linear regression fit. Similarly, scatterplots of IQ scores (y-axis) as a function of FMRP expression show that lower IQs significantly correlate with reduced FMRP expression in fibroblasts (D) and a similar trend can be observed in PBMCs (C). Circles represent observed data, the solid line shows the linear regression fit.