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. 2014 Sep 10;7:23. doi: 10.1186/1756-8935-7-23

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Copyright © 2014 Schones et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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H3K9me2 nucleation and effect on chromatin accessibility is biased towards the low deamination, mostly unmethylated CGIs. (A) H3K9me2 nucleation sites (blue) are biased towards CGIs with low rates of C- > T deamination (green) as compared to CGIs that evolutionarily show G/C gain (red). (B) The increase in chromatin accessibility is more dramatic at the CGIs with low rates of C- > T deamination (green) as compared to CGIs that evolutionarily have G/C gain (red). (C) DNA methylation levels in CD34⁺ HSPCs for CGIs with low rates of C- > T deamination (green) and CGIs displaying G/C gain (red) indicate that the CGIs with low rates of C- > deamination are mostly unmethylated while the GCIs displaying evolutionary gain of G/C content are mostly methylated.