Table 5.

Adjusted hazard ratios for gastric cancer by anatomic site, cigarette smoking status, and sex

	Gastric cardia cancer			Distal gastric cancer			p value for interaction
	Cases	Hazard ratio	95% CI	Cases	Hazard ratio	95% CI
Men (n = 82,683)	87			322
Never smoker	12	1.00		62	1.00
Ever smoker	75	2.60	1.41–4.80	260	1.82	1.38–2.41	0.0015
Former smoker	52	2.28	1.21–4.29	205	1.81	1.36–2.41	0.0077
Current smoker	23	3.97	1.94–8.12	60	1.85	1.28–2.69	0.0001
Women (n = 99,758)	17			202
Never smoker	5	1.00		122	1.00
Ever smoker	12	4.11	1.37–12.30	80	1.25	0.93–1.68	0.0048
Former smoker	9	4.29	1.38–13.35	45	0.98	0.60–1.40	0.0054
Current smoker	3	3.58	0.79–16.24	35	1.99	1.34–2.97	0.0543
Total (n = 182,441)a	104			524
Never smoker	17	1.00		184	1.00
Ever smoker	87	2.86	1.66–4.93	340	1.52	1.25–1.86	<0.0001
Former smoker	61	2.56	1.46–4.49	250	1.44	1.17–1.78	<0.0001
Current smoker	26	4.02	2.11–7.63	90	1.80	1.38–2.36	<0.0001

Adjusted for age at cohort entry as a continuous variable, ethnicity, education, processed meat intake, BMI, alcohol intake, aspirin use, and family history of gastric cancer

^aAdditional adjustment for sex