Table 2.

NIH cGvHD Global and Organ Severity Scores

Score	n (%)
NIH global severity score
1 = mild	3 (3)
2 = moderate	24 (22)
3 = severe	83 (75)
NIH organ severity scores
Skin
0 = none	23 (21)
1 = mild	14 (13)
2 = moderate	24 (22)
3 = severe	48 (44)
Mouth
0 = none	32 (30)
1 = mild	56 (51)
2 = moderate	14 (13)
3 = severe	7 (6)
Eyes
0 = none	27 (25)
1 = mild	38 (35)
2 = moderate	34 (31)
3 = severe	10 (9)
Gastrointestinal tract
0 = none	61 (55)
1 = mild	31 (28)
2 = moderate	6 (5)
3 = severe	11 (10)
Liver
0 = none	52 (47)
1 = mild	36 (33)
2 = moderate	19 (17)
3 = severe	2 (2)
Lungs
0 = none	22 (20)
1 = mild	39 (35)
2 = moderate	38 (34)
3 = severe	10 (9)
Joints and fascia
0 = none	33 (31)
1 = mild	22 (20)
2 = moderate	38 (34)
3 = severe	16 (14)
Female genital
0 = none	31 (28)
1 = mild	6 (5)
2 = moderate	12 (11)
3 = severe	5 (4)

Abbreviations: Mild cGVHD involves only one or two organs or sites with no clinically significant functional impairment (max score 1). Moderate involves at least one organ or site with clinically significant but no major disability (max score 2) or three or more organs or sites with no clinically significant functional impairment (max score 1). A lung score of 1 is also moderate cGVHD. Severe cGVHD indicates major disability caused by cGVHD (score 3). A lung score of 2 or 3 is also classified as severe cGVHD.¹¹