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. Author manuscript; available in PMC: 2014 Sep 18.
Published in final edited form as: Angiogenesis. 2012 Sep 4;16(1):29–44. doi: 10.1007/s10456-012-9297-6

Figure 7. Increased peri-tumoral lymphangiogenesis by IL-8/CXCR2.

Figure 7

Vessel density (a,c) and size (b,d) of LYVE-1-positive peri-tumoral or intra-tumoral lymphatic vessels of tumors of HCT116 human colon cancer cells (a,b) or CT26 mouse colon carcinoma cells (c,d) grown in K14-hIL8/nude versus control nude mice. Six to 8 mice were used per group and tumors were grown for three weeks. Vessel density (e) and size (f) of LYVE-1-positive lymphatic vessels in the peri-tumoral and intra-tumoral areas of CT26-induced tumors in BALB/c wild-type (n=10) versus BALB/c CXCR2 KO (n=10) mice. Tumor-related experiments were performed twice with comparable results. All data are displayed as an average ± standard deviation. *, p < 0.05; **, p < 0.01.